NASA astronauts' blood reveals DNA alterations following spaceflight.

Astronauts' DNA anomalies increase after space travel, which might increase their chance of developing cancer.

The main concern is radiation at high levels. Increased radiation exposure is one of the cancer risk factors.

There were 14 astronauts from the space shuttle. They carried out 12-day shuttle trips between 1998 and 2001.

The typical astronaut was 44 years old. Researchers twice collected whole blood samples.

Prior to takeoff, during landing, and three days after landing for white blood cells. For 20 years, these samples were kept frozen at 112°F.

Researchers discovered that somatic gene mutations in astronauts were greater than in non-astronauts.

Somatic mutations develop in cells other than sperm or egg cells after conception, therefore they are not passed down from parent to child.

The astronauts' mutations induced clonal hematopoiesis, an overrepresentation of single-clone blood cells.

Other blood malignancies and chronic myeloid leukaemia are brought on by this.