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The Buffalo Bills will be greeted in Los Angeles for the first contest.
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The prediction for the contest has been made public by ESPN's Predictive Computer Model.
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According to ESPN, the Rams have a tiny advantage over Buffalo, 49.9 percent to 49.6 percent.
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ESPN gives the Rams a small advantage over the Saints but Vegas goes the other way.
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One of the Super Bowl winners right now is the Buffalo Bills.
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Josh Allen and the Bills are under a lot of pressure to be successful in 2022.
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Allen is expected to win the Super Bowl and is the overwhelming favourite to earn the MVP Award.
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After a fantastic postseason the previous year, the Rams are attempting to defend their championship.